| Identification | Back Directory | [Name]
3-Furansulfonamide, N-[2,4-difluoro-3-[[3-(9H-purin-6-yl)-2-pyridinyl]amino]phenyl]- | [CAS]
1380228-30-7 | [Synonyms]
INU152
INU-152
INU 152
3-Furansulfonamide, N-[2,4-difluoro-3-[[3-(9H-purin-6-yl)-2-pyridinyl]amino]phenyl]- | [Molecular Formula]
C20H13F2N7O3S | [MDL Number]
MFCD28502127 | [MOL File]
1380228-30-7.mol | [Molecular Weight]
469.42 |
| Hazard Information | Back Directory | [Description]
INU-152 is a novel pan-RAF inhibitor with potent anti-tumor activity in preclinical models of BRAFV600E mutant cancer. INU-152 inhibits all RAF isoforms and inhibits MAPK pathways in mutant BRAF cells. More importantly, INU-152 exhibits minimal paradoxical pathway activation in melanoma cells with mutant RAS. INU-152 exhibits anti-tumor activities in xenograft models carrying BRAF mutations | [Uses]
INU-152 is a potent and selective B-Raf inhibitor. INU-152 reduces tumor cell proliferation, enhances autophagy, and induces apoptosis by inhibiting B-Raf activity. INU-152 exhibits significant cytotoxicity against cancer cells transformed with v-Ha-ras (Ras-NIH 3T3). INU-152 can be utilized in cancer research[1]. | [References]
[1] Ahn JH, et al. The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts. Biochem Biophys Res Commun. 2012 Jan 13;417(2):857-63. DOI:10.1016/j.bbrc.2011.12.061 |
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