| Identification | Back Directory | [Name]
Methanone, [5-amino-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-4-piperidinyl- | [CAS]
1381459-14-8 | [Synonyms]
ARN1468
Methanone, [5-amino-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-4-piperidinyl- | [Molecular Formula]
C16H17F3N4O2 | [MOL File]
1381459-14-8.mol | [Molecular Weight]
354.33 |
| Chemical Properties | Back Directory | [Boiling point ]
467.6±45.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.63±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM[1]. | [in vivo]
ARN1468 (compound 5) (3 mg/kg, IV; 10 mg/kg, PO; once) reveals low brain concentrations and high plasma clearance in male C57BL/6 mice[1]. | [References]
[1] Colini Baldeschi A, et al. Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance. J Med Chem. 2022 Jun 30. DOI:10.1021/acs.jmedchem.2c00205 |
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