| Identification | Back Directory | [Name]
Benzenamine, 4-[8,9-dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]- | [CAS]
1382979-64-7 | [Synonyms]
PI3K-IN-38
Benzenamine, 4-[8,9-dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]- | [Molecular Formula]
C20H24N6O2 | [MOL File]
1382979-64-7.mol | [Molecular Weight]
380.45 |
| Hazard Information | Back Directory | [Uses]
PI3K-IN-38 (compound 123) is an orally active PI3K inhibitor with IC50 of 0.541 μM (PI3K-α). PI3K-IN-38 shows activities of anticancer and anti-inflammatory, which inhibis tumor growth in vivo[1]. | [IC 50]
p110α: 0.541 μM (IC50) | [References]
[1] Dotson J, et al. Tricyclic pi3k inhibitor compounds and methods of use. WO2012082997A1. |
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