| Identification | Back Directory | [Name]
9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene | [CAS]
1389439-77-3 | [Synonyms]
9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene
Pyrazolo[4,3-b]pyrido[4,3-e][1,4]diazepine, 5-(2-chlorophenyl)-8-ethyl-1,2-dihydro-3-methyl- | [Molecular Formula]
C18H16ClN5 | [MDL Number]
MFCD19707648 | [MOL File]
1389439-77-3.mol | [Molecular Weight]
337.81 |
| Chemical Properties | Back Directory | [Boiling point ]
541.8±50.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at 0-8 °C | [pka]
16.46±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
TY-011 is an Aurora A/B kinase inhibitor. TY-011 induces abnormal microtubule-kinetochore attachment, leading to DNA damage and apoptosis (Apoptosis) in human gastric cancer cells, and ultimately inhibits cancer cell proliferation, with an IC50 value ranging from 0.11 to 4.49 μM in human gastric cancer cell lines. TY-011 has potential applications in gastric cancer research[1]. | [IC 50]
Aurora A; Aurora B | [References]
[1] Jiang T, et al. Antitumor activity of a novel Aurora A/B kinases inhibitor TY-011 against gastric cancer by inducing DNA damage. Anticancer Drugs. 2020 Jun;31(5):440-451. DOI:10.1097/CAD.0000000000000928 |
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