| Identification | Back Directory | [Name]
sir2-like 6 | [CAS]
NoCAS | [Synonyms]
SIRT6
SIR2L6
sir2-like 6
Sirtuin 6 human
SIRT6 human
Rabbit Anti-SIRT6 antibody
SIRT6, active, His tagged human
NAD-dependent ADP-ribosyltransferase sirtuin-6
Sirtuin (silent mating type information regulation 2 homolog) 6 |
| Chemical Properties | Back Directory | [storage temp. ]
-70°C | [form ]
buffered aqueous glycerol solution | [biological source]
human | [Specific Activity]
96-144RLU/min·ng | [Major Application]
cell analysis |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
61 | [Safety Statements ]
53-45 | [WGK Germany ]
WGK 1 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Eye Irrit. 2
Repr. 1B
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. | [Biological Activity]
Sirtuin 6 (Sir6) is a mono-ADP-ribosyltransferasewhich catalyzes the transfer of ADP-ribose moiety from NAD to itself and histones. It has been implicated in the regulation of DNA repairgenomic stability and telomere integritygene expressionand metabolism. In additionit also prevents age-related disorders and premature aging. Sir6 plays a vital role in the inhibition of nuclear factor-KB (NF-KB)–mediated inflammatory responses in rheumatoid joints. HenceSir6 is considered to be a potent target for treatment of rheumatoid arthritis (RA). Sir6 is also majorly implicated in the regulation of glucose and f at metabolism. Sir6 prevent cardiac hypertrophy in vitro via inhibiting NF-KB-dependent transcriptional activity and this effect is relied on its deacetylase activity. |
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| Company Name: |
Perfect mRNA
|
| Tel: |
4006682586 15252998975 |
| Website: |
www.perfectmrna.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|