| Identification | Back Directory | [Name]
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite | [CAS]
1391728-01-0 | [Synonyms]
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
O-2-cyanoethyl-O'-(3,6-dioxanon-8-ynyl)-N,N-diisopropylphosphoramidite
Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-(2-propyn-1-yloxy)ethoxy]ethyl ester | [Molecular Formula]
C16H29N2O4P | [MDL Number]
MFCD28142480 | [MOL File]
1391728-01-0.mol | [Molecular Weight]
344.39 |
| Hazard Information | Back Directory | [Uses]
Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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