| Identification | Back Directory | [Name]
Propargyl-PEG1-SS-PEG1-t-butyl ester | [CAS]
1807518-78-0 | [Synonyms]
Propargyl-PEG1-SS-PEG1-C2-Boc
Propargyl-PEG1-SS-PEG1-t-butyl ester
Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C14H24O4S2 | [MDL Number]
MFCD28505559 | [MOL File]
1807518-78-0.mol | [Molecular Weight]
320.47 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG1-SS-PEG1-t-butyl ester is a Click Chemistry crosslinker containing a propargyl group that can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The t-butyl protected carboxyl group prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling condition, t-butyl can be deprotected under acidic conditions. | [Uses]
Propargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-C2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker; Disulfide Cleavable Linker; Alkyl/ether | [References]
[1] Barrientos AG, et al. Gold glyconanoparticles: synthetic polyvalent ligands mimicking glycocalyx-like surfaces as tools for glycobiological studies. Chemistry. 2003 May 9;9(9):1909-21. DOI:10.1002/chem.200204544 |
|
|