| Identification | Back Directory | [Name]
FIDAS-5 | [CAS]
1391934-98-7 | [Synonyms]
FIDAS-5
(E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline
Benzenamine, 4-[(1E)-2-(2-chloro-6-fluorophenyl)ethenyl]-N-methyl-
p21WAF1/CIP1,S-adenosylmethionine,inhibit,MAT2A,anti-proliferation,SAH,Inhibitor,FIDAS-5,anti-cancer,CyclinD1,FIDAS5,c-Myc,SAM,FIDAS 5,colorectal | [Molecular Formula]
C15H13ClFN | [MDL Number]
MFCD32671894 | [MOL File]
1391934-98-7.mol | [Molecular Weight]
261.72 |
| Chemical Properties | Back Directory | [Boiling point ]
385.1±30.0 °C(Predicted) | [density ]
1.256±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL | [form ]
Solid | [pka]
4.44±0.38(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C15H13ClFN/c1-18-12-8-5-11(6-9-12)7-10-13-14(16)3-2-4-15(13)17/h2-10,18H,1H3/b10-7+ | [InChIKey]
KXVXICBOMOGFMH-JXMROGBWSA-N | [SMILES]
C1(NC)=CC=C(/C=C/C2=C(F)C=CC=C2Cl)C=C1 |
| Hazard Information | Back Directory | [Uses]
FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
MAT2A''Reversible: yes | [in vivo]
FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight[1].
Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced[1]. | Animal Model: | 16 athymic nude mice injected with HT29 CRC cells[1] | | Dosage: | 20 mg/kg | | Administration: | Oral gavage; daily; for two weeks | | Result: | Significantly inhibited the growth of xenograft tumors.
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| [References]
[1] Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. DOI:10.1021/cb3005353 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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