| Identification | Back Directory | [Name]
4-[(4S,5R)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-bis[4-(trifluoromethyl)phenyl]-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one | [CAS]
1392830-09-9 | [Synonyms]
Caylin-2 Exclusive
4-[(4S,5R)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-bis[4-(trifluoromethyl)phenyl]-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one | [Molecular Formula]
C32H30F6N4O4 | [MDL Number]
MFCD08062138 | [MOL File]
1392830-09-9.mol | [Molecular Weight]
648.595 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2)(1:3): .025 mg/ml | [form ]
A crystalline solid | [pka]
14.26±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Caylin-2 is a Mdm2 inhibitor, an analog of Nutlin-3. | [Uses]
Caylin-2, a Nutlin-3 analog, is a MDM2 inhibitor. Caylin-2 can bind to Bcl-XL[1]. | [storage]
Store at -20°C | [References]
[1] Shin JS, et al. Structural insights into the dual-targeting mechanism of Nutlin-3. Biochem Biophys Res Commun. 2012 Mar 30;420(1):48-53. DOI:10.1016/j.bbrc.2012.02.113 |
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