| Identification | Back Directory | [Name]
IMGN-779 | [CAS]
1394079-41-4 | [Synonyms]
DGN-462
IMGN-779
IMGN779-Linker
6H-Indolo[2,1-c][1,4]benzodiazepin-6-one, 9-[[3-[[[(12aS)-12a,13-dihydro-8-methoxy-6-oxo-6H-indolo[2,1-c][1,4]benzodiazepin-9-yl]oxy]methyl]-5-[(2-mercapto-2-methylpropyl)[2-[2-(2-methoxyethoxy)ethoxy]ethyl]amino]phenyl]methoxy]-11,12,12a,13-tetrahydro-8-methoxy-, (12aS)- | [Molecular Formula]
C53H59N5O9S | [MDL Number]
MFCD34469128 | [MOL File]
1394079-41-4.mol | [Molecular Weight]
942.13 |
| Hazard Information | Back Directory | [Uses]
DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1]. | [References]
[1] Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639. DOI:10.3324/haematol.2018.211011 |
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| Company Name: |
Abydos Scientific
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| Tel: |
025-84767922 18936879710 |
| Website: |
http://www.abydoscientific.com/index.html |
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