| Identification | Back Directory | [Name]
SUVN-G3031 | [CAS]
1394808-82-2 | [Synonyms]
SUVN-G3031
Samelisant (SUVN-G3031)
N-(4-((1-cyclobutylpiperidin-4-yl)oxy)phenyl)-2-morpholinoacetamide
4-Morpholineacetamide, N-[4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl]- | [Molecular Formula]
C21H31N3O3 | [MDL Number]
MFCD32206947 | [MOL File]
1394808-82-2.mol | [Molecular Weight]
373.49 |
| Hazard Information | Back Directory | [Uses]
Samelisant is a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy. | [in vivo]
Treatment with Samelisant (10 and 30 mg/kg, p.o.) free base produces a significant increase in wakefulness with a concomitant decrease in non-rapid eye movement sleep (NREM) sleep in orexin knockout mice subjected to sleep electroencephalography (EEG)[1].
Samelisant free base also produces a significant decrease in direct rapid eye movement (REM) sleep onset (DREM) episodes, demonstrating its anticataplectic effects in an animal model relevant to narcolepsy[1].
Samelisant free base treatment in mice produces a dose-dependent increase in tele-methylhistamine levels indicating the activation of histaminergic neurotransmission[1]. | Animal Model: | Male Wistar rats or male C57BL6J mice[1] | | Dosage: | 1, 3, 10, and 30 mg/kg | | Administration: | Oral administration | | Result: | Produced a dose-dependent increase in t-MH levels in the frontal cortex, hypothalamus and cerebrospinal fluid (CSF) of male Wistar rats. Produced a significant increase in t-MH levels of the frontal cortex, striatum and hypothalamus in mice.
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| Company Name: |
ChemShuttle, Inc.
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| Tel: |
0510-83588313-811 18800520310 |
| Website: |
https://www.jiehuapharma.com/ |
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