| Identification | Back Directory | [Name]
Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane | [CAS]
1398044-51-3 | [Synonyms]
Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane
2-?Azido-?6,?6-?bis[(2-?carboxyethoxy)?methyl]?-?8-?oxo-4,?11,?14,?17,?20-?pentaoxa-?7-?azadocosanoic Acid | [Molecular Formula]
C24H42N4O14 | [MDL Number]
MFCD22574790 | [MOL File]
1398044-51-3.mol | [Molecular Weight]
610.61 |
| Hazard Information | Back Directory | [Description]
Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane is a branched PEG linker with a terminal azide group and three terminal carboxylic acids. The azide group enables PEGylation via Click Chemistry. | [Uses]
Azido-PEG4-amido-tri-(carboxyethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-amido-tri-(carboxyethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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