| Identification | Back Directory | [Name]
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane | [CAS]
1421933-29-0 | [Synonyms]
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane | [Molecular Formula]
C36H66N4O14 | [MDL Number]
MFCD22574791 | [MOL File]
1421933-29-0.mol | [Molecular Weight]
778.94 |
| Hazard Information | Back Directory | [Description]
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a branched PEGylation compound with a terminal azide group and three t-butyl groups. The t-butyl groups can be removed under acidic conditions. The azide group can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form stable triazole linkages. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | [Uses]
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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