| Identification | Back Directory | [Name]
4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile | [CAS]
1399177-37-7 | [Synonyms]
TVB2640
TVB-2640
FASN-IN-2
EOS-61292
FASN inhibitor 2
4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile
Benzonitrile, 4-[1-[4-cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl]-4-piperidinyl]- | [Molecular Formula]
C27H29N5O | [MOL File]
1399177-37-7.mol | [Molecular Weight]
439.55 |
| Chemical Properties | Back Directory | [Boiling point ]
708.3±70.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
9.96±0.40(Predicted) | [color ]
White to off-white | [InChIKey]
BBGOSBDSLYHMRA-UHFFFAOYSA-N | [SMILES]
C(#N)C1=CC=C(C2CCN(C(=O)C3=CC(C4NN=C(C)N=4)=C(C4CCC4)C=C3C)CC2)C=C1 |
| Hazard Information | Back Directory | [Uses]
Denifanstat (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. Denifanstat has the potential for fatty liver disease and cancer research[1][2]. | [References]
[1] Minhyoung Lee, et al. Fatty Acid Synthase inhibition prevents palmitoylation of SARS-CoV2 Spike Protein and improves survival of mice infected with murine hepatitis virus. BioRxiv, December 21, 2020.
[2] Johan D., et al. Heterocyclic modulators of lipid synthesis. WO2012122391A1. |
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| Company Name: |
TOSUN PHARM
|
| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
| Company Name: |
DC Chemicals
|
| Telephone: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm |
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