| Identification | Back Directory | [Name]
1843U89 | [CAS]
139987-54-5 | [Synonyms]
C11374
Gw1843
1843U89
OSI7904
OSI-7904
OSI 7904
OSI-7904L
BW 1843U89
OSI-7904L free acid
OSI-7904L/GW1843/1843U89/OSI-7904
OSI 7904L free acid,OSI7904L free acid
(S)-2-(5-(((3-METHYL-1-OXO-1,2-DIHYDROBENZO[F]QUINAZOLIN-9-YL)METHYL)AMINO)-1-OXOISOINDOLIN-2-YL)PENTANEDIOIC ACID
(2S)-2-(5-{[(3-Methyl-1-oxo-1,2-dihydrobenzo[f]quinazolin-9-yl)me thyl]amino}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid
Pentanedioic acid, 2-[5-[[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, (2S)-
1843U89:(2S)-2-(5-{[(3-Methyl-1-oxo-1,2-dihydrobenzo[f]quinazolin-9-yl)me thyl]amino}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid | [Molecular Formula]
C27H24N4O6 | [MDL Number]
MFCD00871785 | [MOL File]
139987-54-5.mol | [Molecular Weight]
500.5 |
| Hazard Information | Back Directory | [Uses]
OSI-7904L (GW1843) is a noncompetitive inhibitor of thymidylate synthase (TS). OSI-7904L is an antifolate compound and a substrate for folylpolyglutamate synthetase. OSI-7904L has cytotoxicity against solid tumor lines, and the toxicity can be selectively blocked by folic acid[1]. | [References]
[1] Schwartz G, et al. A phase I and pharmacokinetic study of 1843U89, a noncompetitive inhibitor of thymidylate synthase, in patients with advanced solid malignancies. Clin Cancer Res. 2001 Jul;7(7):1901-11. PMID:11448903 |
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| Company Name: |
AstaTech, Inc
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| Tel: |
(215) 785 3197 |
| Website: |
www.astatechinc.com |
| Company Name: |
ARENA CHEMICAL
|
| Tel: |
33 979 998 163 |
| Website: |
www.arenachemical.com |
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