| Identification | Back Directory | [Name]
CORT 118335 | [CAS]
1400902-13-7 | [Synonyms]
C118335)
CORT 118335
Miricorilant
CORT 118335
(Miricorilant
2,4(1H,3H)-Pyrimidinedione, 6-(trans-4-phenylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]methyl]- | [Molecular Formula]
C24H23F3N2O2 | [MOL File]
1400902-13-7.mol | [Molecular Weight]
428.45 |
| Hazard Information | Back Directory | [Uses]
Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders[1]. | [in vivo]
CORT 118335 (3-30 mg/kg) potently suppresses endocrine responses to two different stressors (restraint and FST) in male rats[1]. | Animal Model: | Male Sprague-Dawley rats (≈250 g)[1] | | Dosage: | 3 mg/kg, 10 mg/kg, 30 mg/kg | | Administration: | Subcutaneously (s.c.); five days. | | Result: | 30 mg/kg had lower corticosterone responses relative to 10 mg/kg at 15 and 30 min time points. |
| [References]
[1] Elizabeth T Nguyen, et al. A Mixed Glucocorticoid/Mineralocorticoid Receptor Modulator Dampens Endocrine and Hippocampal Stress Responsivity in Male Rats. Physiol Behav. 2017 Sep 1;178:82-92. DOI:10.1016/j.physbeh.2017.01.020 |
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