| Identification | Back Directory | [Name]
MRT00033659 | [CAS]
1401731-54-1 | [Synonyms]
MRT00033659
MRT-00033659,MRT00033659
Acetamide, N-[3-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl]- | [Molecular Formula]
C15H14N4O | [MDL Number]
MFCD32671318 | [MOL File]
1401731-54-1.mol | [Molecular Weight]
266.3 |
| Chemical Properties | Back Directory | [Boiling point ]
585.6±50.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.99±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation[1]. | [IC 50]
CKIδ: 0.9 μM (IC50); Chk1: 0.23 μM (IC50) | [References]
[1] Huart AS, et al. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novelactivator of the p53 pathway. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5578-85. DOI:10.1016/j.bmcl.2013.08.046 |
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