| Identification | Back Directory | [Name]
Azido-PEG5-succinimidyl carbonate | [CAS]
1402411-88-4 | [Synonyms]
Azido-PEG5-succinimidyl carbonate | [Molecular Formula]
C17H28N4O10 | [MDL Number]
MFCD31380400 | [MOL File]
1402411-88-4.mol | [Molecular Weight]
448.43 |
| Hazard Information | Back Directory | [Description]
Azido-PEG5-succinimidyl carbonate is a PEG linker containing active azide and succinimidyl carbonate moieties. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The succinimidyl carbonate is a good leaving group and commonly reacts with amine nucleophiles. The 5 PEG unitsr increases the water solubility of the compound. | [Uses]
Azido-PEG5-succinimidyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-succinimidyl carbonate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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