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1402931-65-0

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1402931-65-0 Structure

1402931-65-0 Structure

Identification	Back Directory
[Name] eIF4A3-IN-14
[CAS] 1402931-65-0
[Synonyms] eIF4A3-IN-14
[Molecular Formula] C27H27NO7
[MOL File] 1402931-65-0.mol
[Molecular Weight] 477.51

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[Boiling point ] 643.619±55.00 °C(Press: 760.00 Torr)(predicted)
[density ] 1.390±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ] Solid
[pka] 11.758±0.70(predicted)
[color ] White to off-white

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[Uses] eIF4A3-IN-14 (compound 51) is a silvestrol (HY-13251) analogue. eIF4A3-IN-14 interferes the assembling of eIF4F translation complex with EC50s of 40 and 50 nM for myc-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-14 can be used for the research of human cancer pathogenesis[1].
[References] [1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542

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