| Identification | Back Directory | [Name]
eIF4A3-IN-2 | [CAS]
2095677-20-4 | [Synonyms]
eIF4A3-IN-2
eIF4A3 inhibitor 2
eIF4A3 IN 2,eIF-4A3-IN-2,eIF4A3IN2
Methanone, [(3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)-1-piperazinyl](6-bromopyrazolo[1,5-a]pyridin-3-yl)- | [Molecular Formula]
C25H19Br2ClN4O2 | [MOL File]
2095677-20-4.mol | [Molecular Weight]
602.71 |
| Chemical Properties | Back Directory | [density ]
1.68±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (165.92 mM; Need ultrasonic) | [form ]
Solid | [pka]
0.89±0.30(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1]. | [IC 50]
eIF4 | [storage]
Store at -20°C | [References]
[1] Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768. DOI:10.1021/acschembio.7b00041 |
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