ChemicalBook--->CAS DataBase List--->1407495-02-6

1407495-02-6

1407495-02-6 Structure

1407495-02-6 Structure
IdentificationBack Directory
[Name]

Bococizumab
[CAS]

1407495-02-6
[Synonyms]

Bococizumab
Research Grade Bococizumab(DHJ24004)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Bococizumab (PF-04950615) is an anti-human PCSK9 inhibitory antibody that reduces LDL cholesterol levels. Bococizumab can be used in the research of hypercholesterolemia[1][2].
[in vivo]

Bococizumab (0-100 mg/kg, i.v.) decreases maternal and fetal cholesterol and does not affect rat embryo-fetal development[2].

Animal Model:Pregnant Sprague-Dawley (SD) rats[1]
Dosage:0, 10, 30, and 100 mg/kg
Administration:Intravenous injection (i.v.)
Result:Decreased in fetal cholesterol levels.
Showed well tolerance and no effects on ovarian or uterine parameters.
[References]

[1] Koutaro Yokote, et al. Efficacy and Safety of Bococizumab (RN316/PF-04950615), a Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, in Hypercholesterolemic Japanese Subjects Receiving a Stable Dose of Atorvastatin or Treatment-Naive - Results From a Randomized, Placebo-Controlled, Dose-Ranging Study. Circ J. 2017 Sep 25;81(10):1496-1505. DOI:10.1253/circj.CJ-16-1310
[2] Sarah N Campion, et al. Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development. Regul Toxicol Pharmacol. 2015 Nov;73(2):562-70. DOI:10.1016/j.yrtph.2015.08.007
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