| Identification | Back Directory | [Name]
(+)-ITD 1 | [CAS]
1409968-46-2 | [Synonyms]
(+)-ITD-1
3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester, (4R)- | [Molecular Formula]
C27H29NO3 | [MOL File]
1409968-46-2.mol | [Molecular Weight]
415.52 |
| Hazard Information | Back Directory | [Uses]
(+)-ITD-1 is an inhibitor for TGF-β, that inhibits the TGF-β2 with an IC50 of 0.46 μM. (+)-ITD-1 promotes the degradation of TGF-b type II receptor (TGFBR2) and the differentiation of cardiomyocyte, and inhibits the mesoderm formation in the early differentiation stage of mouse embryonic stem cells (mESCs)[1]. | [References]
[1] Willems E, et al., Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11(2):242-52. DOI:10.1016/j.stem.2012.04.025 |
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