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1410738-90-7

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1410738-90-7 Structure

1410738-90-7 Structure
IdentificationBack Directory
[Name]

Benzoic acid, 4-[[[(3'S,4'R,5'S)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'',2''-dihydro-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indol]-5'-yl]carbonyl]amino]-
[CAS]

1410738-90-7
[Synonyms]

Benzoic acid, 4-[[[(3'S,4'R,5'S)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'',2''-dihydro-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indol]-5'-yl]carbonyl]amino]-
[Molecular Formula]

C30H26Cl2FN3O4
[MOL File]

1410738-90-7.mol
[Molecular Weight]

582.45
Chemical PropertiesBack Directory
[Boiling point ]

808.2±65.0 °C(Predicted)
[density ]

1.51±0.1 g/cm3(Predicted)
[pka]

4.22±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

(S,R,S)-MI-1061 is the isomer of MI-1061(HY-125858). (S,R,S)-MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs). MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].
[References]

[1] Nathan FISHKIN, et al. Linkers for use in antibody drug conjugates. WO2023037268A1.
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