| Identification | Back Directory | [Name]
Acetylene-linker-Val-Cit-PABC-MMAE | [CAS]
1411977-95-1 | [Synonyms]
LCB14-0602
Acetylene-linker-Val-Cit-PABC-MMAE
L-Valinamide, N-methyl-N-[[[4-[[N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]acetyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-... | [Molecular Formula]
C67H106N10O16 | [MDL Number]
MFCD29924790 | [MOL File]
1411977-95-1.mol | [Molecular Weight]
1307.62 |
| Chemical Properties | Back Directory | [Boiling point ]
1312.0±65.0 °C(Predicted) | [density ]
1.177±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.22±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE). Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a agent-linker conjugate for ADC. Acetylene-linker-Val-Cit-PABC-MMAE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Auristatin | [References]
[1] PROTEIN-ACTIVE AGENT CONJUGATES AND METHOD FOR PREPARING THE SAME. WIPO Patent Application WO/2012/153193. |
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