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2680543-57-9

2680543-57-9 Structure

2680543-57-9 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2680543-57-9
[Synonyms]

MC-VA-PAB-Exatecan
[Molecular Formula]

C50H54FN7O11
[MOL File]

2680543-57-9.mol
[Molecular Weight]

948
Chemical PropertiesBack Directory
[Boiling point ]

1276.1±65.0 °C(Predicted)
[density ]

1.44±0.1 g/cm3(Predicted)
[solubility ]

DMSO : 100 mg/mL (105.49 mM; Need ultrasonic)
[form ]

Solid
[pka]

10.74±0.40(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity[1].
[IC 50]

Camptothecins
[References]

[1] KRAIEM, et al. Treatment of cancer. WO2021151984A1.
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