| Identification | Back Directory | [Name]
SB 201146 | [CAS]
141311-11-7 | [Synonyms]
SB 201146
(E)-3-[6-[(3-aminophenyl)sulfinylmethyl]-3-[8-(4-methoxyphenyl)octoxy]pyridin-2-yl]prop-2-enoate | [Molecular Formula]
C30H35LiN2O5S | [MOL File]
141311-11-7.mol | [Molecular Weight]
542.615 |
| Hazard Information | Back Directory | [Description]
SB 201146 is a leukotriene B4 antagonist. SB 201146 is a trisubstituted pyridine with high affinity for the LTB4 receptor. | [Uses]
SB 201146 is an LTB4 receptor antagonist with a potency range of 10 pM to 1 μM that plays a critical role in asthma-associated airway inflammation. Studies have focused on its effects on eosinophil survival, a hallmark of asthma pathology. Studies have shown that eosinophil-derived cysteinyl leukotrienes, including LTC4 and LTD4, as well as factors such as GM-CSF and fibronectin promote eosinophil survival. SB 201146 effectively reversed mast cell- and lymphocyte-induced eosinophil survival, highlighting its potential therapeutic role in disrupting the autocrine cysteinyl leukotriene pathway that maintains eosinophil viability. This antagonist also highlights the importance of LTB4 as a paracrine mediator that influences eosinophil survival in inflammatory settings such as asthma[1]. | [References]
[1] Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals |
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| Company Name: |
CHEMICAL LAND21
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| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
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