| Identification | Back Directory | [Name]
BIIL 284 | [CAS]
346735-24-8 | [Synonyms]
BIIL 284
Amelubant
Amelubant
(BIIL284
Carbamic acid, N-[[4-[[3-[[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenoxy]methyl]phenyl]methoxy]phenyl]iminomethyl]-, ethyl ester | [Molecular Formula]
C33H34N2O5 | [MDL Number]
MFCD04034629 | [MOL File]
346735-24-8.mol | [Molecular Weight]
538.63 |
| Chemical Properties | Back Directory | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.83±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. | [IC 50]
LTB4: 221 nM (Ki, in vital human granulocytes); LTB4: 230 nM (Ki, in cell membranes) | [storage]
Store at -20°C | [References]
[1] Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66. PMID:11259574 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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