| Identification | More | [Name]
4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE | [CAS]
141337-26-0 | [Synonyms]
4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE
4-CHLORO-2-FLUOROBENZENESULPHONYL CHLORIDE
Benzenesulfonyl chloride, 4-chloro-2-fluoro-(9CI)
4-Chloro-2-fluorobenzenesulphonyl chloride 97%
4-Chloro-2-fluorobenzenesulphonylchloride97% | [Molecular Formula]
C6H3Cl2FO2S | [MDL Number]
MFCD03094560 | [Molecular Weight]
229.06 | [MOL File]
141337-26-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
34-38 °C(lit.) | [Boiling point ]
257.4±20.0℃ (760 Torr) | [density ]
1.610±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
>230 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
crystals | [color ]
White | [Sensitive ]
Moisture Sensitive | [InChI]
1S/C6H3Cl2FO2S/c7-4-1-2-6(5(9)3-4)12(8,10)11/h1-3H | [InChIKey]
ZFZRENUEJCOCRE-UHFFFAOYSA-N | [SMILES]
Fc1cc(Cl)ccc1S(Cl)(=O)=O | [CAS DataBase Reference]
141337-26-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
2904990090 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Skin Corr. 1B |
| Hazard Information | Back Directory | [Uses]
4-Chloro-2-fluorobenzenesulfonyl chloride (4-chloro-2-fluorobenzene-1-sulfonyl chloride) may be used to synthesize [1-(4-chloro-2-fluorophenylsulfonyl) piperidin-4-yl] diphenylmethanol. | [Synthesis]
General procedure for the synthesis of 4-chloro-2-fluorobenzenesulfonyl chloride from 4-chloro-2-fluoroaniline:
1. 4-Chloro-2-fluoroaniline (22.90 g, 151 mmol) was dissolved in 120 mL of acetic acid and 80 mL of concentrated hydrochloric acid was added with stirring.
2. the reaction mixture was cooled to 0 °C and a solution of sodium nitrite (27.2 g, 0.4 mol) dissolved in 40 mL of water was added over 10 minutes.
3. The reaction mixture was stirred at 0 °C for 30 min.
4. in another flask, cuprous chloride (500 mg) was dissolved in 200 mL of acetic acid.
5. The flask was cooled to 0 °C and sulfur dioxide gas was passed into the solution for 40 min.
6. The diazonium salt solution prepared in step 3 was slowly added to the solution containing cuprous chloride and sulfur dioxide over a period of 20 minutes, at which time vigorous gas escape was observed.
7. After the addition, the ice bath is removed and the reaction mixture is allowed to gradually warm to room temperature.
8. The reaction mixture was poured into 500 g of crushed ice and the precipitated solid product was collected, washed and dried to give 26.1 g (73% yield) of 4-chloro-2-fluorobenzenesulfonyl chloride. | [References]
[1] Patent: US2003/232859, 2003, A1. Location in patent: Page 56
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 22, p. 9539 - 9553 |
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