| Hazard Information | Back Directory | [Description]
A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tissues. A 78773 acts against inflammation and allergy, edema, inflammatory cell influx, and bronchospasm. It may treat asthma and inflammatory bowel disease. | [Uses]
A-78773 is a 5-lipoxygenase inhibitor. A-78773 can inhibit the formation of LTB4 in human whole blood and human neutrophils, with IC50 values of 85 nM and 20 nM, respectively. A-78773 can be used in the study of inflammation-related diseases[1]. | [References]
[1] Basha A, et al. Second generation leukotriene biosynthesis inhibitors[J]. Pure and applied chemistry, 1994, 66(10-11): 2197-2200. |
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