| Identification | Back Directory | [Name]
Mal-Amido-PEG4-t-butyl ester | [CAS]
1415800-35-9 | [Synonyms]
Mal-NH-PEG4-OtBu
Mal-Amido-PEG4-Boc
MAL-NH-PEG4-CH2CH2COOTBU
Mal-Amido-PEG4-t-butyl ester
Maleimide-C2-Amido-PEG4-Carboxylic Acid tert-Butyl Ester
N-(18,18-Dimethyl-15-oxo-3,6,9,12,17-pentaoxanonadec-1-yl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide
4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C22H36N2O9 | [MDL Number]
MFCD22683312 | [MOL File]
1415800-35-9.mol | [Molecular Weight]
472.53 |
| Hazard Information | Back Directory | [Description]
Mal-Amido-PEG4-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Nextpeptide Inc
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+86-0571-81612335 +8613336028439 |
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http://www.nextpeptide.com/ |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
| Company Name: |
Bide Pharmatech Ltd.
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400-1647117 13681763483 |
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https://www.bidepharm.com/ |
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