| Identification | Back Directory | [Name]
N-Mal-N-bis(PEG2-t-butyl ester) | [CAS]
2100306-51-0 | [Synonyms]
N-Mal-N-bis(PEG2-C2-Boc)
N-Mal-N-bis(PEG2-t-butyl ester)
4,7,13,16-Tetraoxa-10-azanonadecanedioic acid, 10-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-, 1,19-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C29H48N2O11 | [MDL Number]
MFCD29912830 | [MOL File]
2100306-51-0.mol | [Molecular Weight]
600.698 |
| Chemical Properties | Back Directory | [Boiling point ]
671.9±55.0 °C(Predicted) | [density ]
1.154±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
-0.93±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
N-Mal-N-bis(PEG2-t-butyl ester) is a branched maleimide ester. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The t-butyl pester can be hydrolyzed under mild acidic conditions. | [Uses]
N-Mal-N-bis(PEG2-C2-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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