| Identification | Back Directory | [Name]
Bromoacetamido-PEG2-Acid | [CAS]
1415800-44-0 | [Synonyms]
CAS_1415800-44-0
Bromoacetamido-PEG2-Acid
Bromoacetamido-PEG2-C2-acid
Bromoacetamido-PEG2-CH2CH2COOH
3-(2-(2-(2-Bromoacetamido)ethoxy)ethoxy)propanoic acid | [Molecular Formula]
C9H16BrNO5 | [MDL Number]
MFCD22683317 | [MOL File]
1415800-44-0.mol | [Molecular Weight]
298.13 |
| Chemical Properties | Back Directory | [Boiling point ]
491.4±45.0 °C(Predicted) | [density ]
1.464±0.06 g/cm3(Predicted) | [form ]
Solid-Liquid Mixture | [pka]
4.28±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bromoacetamido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Henan Alfachem Co.,Ltd.
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| Tel: |
0371-55051623 18137891487 |
| Website: |
www.chemicalbook.com/supplier/14555231/ |
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