| Identification | Back Directory | [Name]
Bromoacetamido-PEG4-t-Butyl Ester | [CAS]
1807521-00-1 | [Synonyms]
CAS_1807521-00-1
BrCH2CONH-PEG4-COOtBu
Bromoacetamido-PEG4-C2-Boc
Bromoacetamido-PEG4-t-Butyl Ester
Bromoacetamido-PEG5-t-Butyl Ester
4,7,10,13-Tetraoxa-16-azaoctadecanoic acid, 18-bromo-17-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C17H32BrNO7 | [MDL Number]
MFCD28505519 | [MOL File]
1807521-00-1.mol | [Molecular Weight]
442.34 |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG4-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromoacetamido-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl/ether; PEGs | [References]
[1] Darren H. Wakefield, et al. Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1. |
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