| Identification | Back Directory | [Name]
4-AMINO-6-CHLORO-PYRIMIDINE-5-CARBALDEHYDE | [CAS]
14160-93-1 | [Synonyms]
RARECHEM AK ML 0569
4-aMino-6-chloropyriMidin-5-carbaldehyde
4-AMINO-6-CHLORO-5-PYRIMIDINECARBALDEHYDE
4-Chloro-6-aminopyrimidine-5-carbaldehyde
4-aMino-6-chloro-pyriMidine-5-carbaledhyde
5-PyriMidinecarbaldehyde, 4-aMino-6-chloro
4-AMINO-6-CHLORO-PYRIMIDINE-5-CARBALDEHYDE
4-AMINO-6-CHLORO-5-PYRIMIDINECARBOXALDEHYDE
4-Amino-6-chloropyrimidine-5-carboxaldehyde
5-PyriMidinecarboxaldehyde, 4-aMino-6-chloro-
4-Amino-6-chloropyrimidine-5-carboxaldehyde,97%
4-Amino-6-chloro-5-pyrimidinecarboxaldehyde ,96%
4-AMINO-6-CHLORO-PYRIMIDINE-5-CARBALDEHYDE ISO 9001：2015 REACH
4-Amino-6-chloro-5-formylpyrimidine, 4-Amino-6-chloro-5-formyl-1,3-diazine | [EINECS(EC#)]
238-005-7 | [Molecular Formula]
C5H4ClN3O | [MDL Number]
MFCD03789626 | [MOL File]
14160-93-1.mol | [Molecular Weight]
157.56 |
| Chemical Properties | Back Directory | [Melting point ]
>300°C | [Boiling point ]
355.9±42.0 °C(Predicted) | [density ]
1.548±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Solid | [pka]
0.72±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C5H4ClN3O/c6-4-3(1-10)5(7)9-2-8-4/h1-2H,(H2,7,8,9) | [InChIKey]
GOJNFUXEBVBARW-UHFFFAOYSA-N | [SMILES]
C1=NC(Cl)=C(C=O)C(N)=N1 | [EPA Substance Registry System]
5-Pyrimidinecarboxaldehyde, 4-amino-6-chloro- (14160-93-1) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow solid | [Uses]
4-Amino-6-chloropyrimidine-5-carbaldehyde is an important pharmaceutical intermediate compound that can be used in the preparation of ENPP1 inhibitors [1]. Furthermore, it serves as a key starting material for the synthesis of novel 4-amino-pyrimidine-5-formyl oxime VEGFR-2 inhibitors [2]. | [References]
[1] Sun, Y., Chen, M., Han, Y. (2024). Discovery of Pyrido[2,3-d]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment. Journal of Medicinal Chemistry, 67 5, 3986–4006. https://doi.org/10.1021/acs.jmedchem.3c02288
[2] Huang, S., Li, R., LaMontagne, K. R., Greenberger, L. M., & Connolly, P. J. (2011). 4-Aminopyrimidine-5-carbaldehyde oximes as potent VEGFR-2 inhibitors. Part II. Bioorganic & Medicinal Chemistry Letters, 21 6, Pages 1815-1818. https://doi.org/10.1016/j.bmcl.2011.01.053
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