| Identification | Back Directory | [Name]
Ambient temperature | [CAS]
1416711-60-8 | [Synonyms]
DBCO-mPEG, 5 kDa
DBCO-mPEG, 10 kDa
DBCO-mPEG, 20 kDa
DBCO-mPEG, 30 kDa
DBCO-PEG4-Hydroxyl
Ambient temperature
Sulfo DBCO-PEG4-Amine
DBCO-PEG4-Hydroxyl,DBCO-PEG4-OH
DBCO-PEG4-alcohol, DBCO-PEG4-OH
Dibenzoazacyclooctyne-tetra(ethylene glycol) | [Molecular Formula]
C29H36N2O6 | [MDL Number]
MFCD23097051 | [MOL File]
1416711-60-8.mol | [Molecular Weight]
508.606 |
| Hazard Information | Back Directory | [Description]
DBCO-PEG4-alcohol is a PEG linker containing a DBCO moiety and a terminal primary hydroxyl group. The hydroxyl can react with a variety of functional groups and the hydrophilic PEG spacer arm can provide better solubility to labeled molecules. DBCO is commonly used for copper-free Click Chemistry reactions. | [Uses]
DBCO-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG4-alcohol is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [Definition]
The temperature of the environment in which an experiment is conducted or in which any physical or chemical event occurs. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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