1418131-46-0

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1418131-46-0 Structure

Identification	Back Directory
[Name] RSC 133
[CAS] 1418131-46-0
[Synonyms] RSC 133 RSC133,RSC 133 Reprogramming stimulating compound 133 3-[[(E)-3-(1H-indol-3-yl)prop-2-enoyl]amino]benzamide 3-[[(2E)-3-(1H-Indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide Benzamide, 3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]-
[Molecular Formula] C18H15N3O2
[MOL File] 1418131-46-0.mol
[Molecular Weight] 305.33

Chemical Properties	Back Directory
[Boiling point ] 653.7±55.0 °C(Predicted)
[density ] 1.372±0.06 g/cm3(Predicted)
[storage temp. ] -20°C
[solubility ] DMSO: soluble20mg/mL, clear
[form ] powder
[pka] 13.22±0.70(Predicted)
[color ] white to light brown

Hazard Information	Back Directory
[Description] RSC-133 is an indole compound that promotes the reprogramming of human somatic cells to pluripotent stem cells. Specifically, when used at 10 μM with four standard reprogramming factors, it increases the number of human foreskin fibroblasts that express the stem cell marker alkaline phosphatase. RSC-133 induces pluripotency by both down-regulating inducers of cellular senescence and inhibiting DNA methyltransferase and histone deacetylase activities.
[Uses] RSC 133 is a potent chemical booster for human somatic cell reprogramming. RSC 133 facilitates the maintenance of pluripotent human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs).
[References] [1] DR. JUNGWOON LEE. A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells?[J]. Angewandte Chemie International Edition, 2012, 51 50: 12509-12513. DOI: 10.1002/anie.201206691

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