| Identification | Back Directory | [Name]
1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester | [CAS]
1418747-15-5 | [Synonyms]
1-Boc-3-(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-azetidine
1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H19N5O3 | [MOL File]
1418747-15-5.mol | [Molecular Weight]
317.34 |
| Chemical Properties | Back Directory | [Boiling point ]
490.3±55.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
1.11±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50?value of 26 μM?in an enzymatic chromogenic assay. AZ3976 is active with an IC50?of 16 μM in a plasma clot lysis assay.?AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay[1]. | [References]
[1] Ola Fjellstr?m, et al. Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation. J Biol Chem. 2013 Jan 11;288(2):873-85. DOI:10.1074/jbc.M112.371732 |
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