| Identification | Back Directory | [Name]
2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro- | [CAS]
1420844-62-7 | [Synonyms]
Melanin probe-1
2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro- | [Molecular Formula]
C12H18FN3O | [MDL Number]
MFCD32693924 | [MOL File]
1420844-62-7.mol | [Molecular Weight]
239.29 |
| Chemical Properties | Back Directory | [Boiling point ]
370.3±37.0 °C(Predicted) | [density ]
1.102±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (1044.76 mM) | [form ]
Oil | [pka]
13.30±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability[1]. | [in vivo]
Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency[1].
Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection[1]. | Animal Model: | C57BL/6 mice bearing B16F10 murine melanomas[1] | | Dosage: | 3.7 MBq (100 μCi) | | Administration: | Tail vein | | Result: | The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively. |
| [storage]
Store at -20°C | [References]
[1] Liu H, et al. Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma. J Med Chem. 2013;56(3):895‐901. DOI:10.1021/jm301740k |
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MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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