| Identification | More | [Name]
STRYCHNINE HYDROCHLORIDE | [CAS]
1421-86-9 | [Synonyms]
STRYCHNINE HCL
STRYCHNINE HYDROCHLORIDE
strychnidin-10-one,monohydrochloride
strychnine,monohydrochloride
Strychnine Hydrochloride Hydrate | [EINECS(EC#)]
215-826-9 | [Molecular Formula]
C21H23ClN2O2 | [MDL Number]
MFCD00058174 | [Molecular Weight]
370.87 | [MOL File]
1421-86-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
295 °C | [storage temp. ]
Store at RT | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Sparingly, Slightly) | [form ]
Solid | [color ]
White to Light Beige | [Merck ]
8855 | [Stability:]
Hygroscopic | [InChIKey]
VLXYTKMPCOQKEM-ZEYGOCRCSA-N | [SMILES]
Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H] | [CAS DataBase Reference]
1421-86-9(CAS DataBase Reference) | [EPA Substance Registry System]
Strychnine hydrochloride (1421-86-9) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,N | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S60:This material and/or its container must be disposed of as hazardous waste . | [RIDADR ]
UN 1692 6.1/PG 1
| [WGK Germany ]
3
| [RTECS ]
WL2430000
| [HazardClass ]
6.1(a) | [PackingGroup ]
I | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Uses]
Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions. | [Uses]
Strychnine Hydrochloride acts as an antagonist for cholinesterases and beta amyloid aggregation. | [Definition]
ChEBI: A hydrochloride obtained by combining strychnine with one molar equivalent of hydrogen chloride. | [Biological Activity]
Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α 7 receptors and non-competitive antagonism at α 4 β 2 receptors. | [Biochem/physiol Actions]
Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant. |
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