| Identification | Back Directory | [Name]
AC 186 | [CAS]
1421854-16-1 | [Synonyms]
AC 186
4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Phenol, 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]- | [Molecular Formula]
C18H17F3O | [MDL Number]
MFCD28502295 | [MOL File]
1421854-16-1.mol | [Molecular Weight]
306.32 |
| Hazard Information | Back Directory | [Uses]
AC 186 is a selective estrogen receptor β (ERβ) agonist moderates cognitive deficits and amyloid-β levels in a mouse model of Alzheimer’s Disease. AC 186 also shows gender specific neuroprotection in a Parkinsons disease rat model. | [in vivo]
AC-186 (10 mg/kg; s.c.; once) exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease[1]. | Animal Model: | Male Sprague-Dawley rats ( 225-250 g) induced through bilateral 6-hydroxydopamine lesions of the substantia nigra[1]. | | Dosage: | 10 mg/kg | | Administration: | s.c.; once | | Result: | Prevented motor, cognitive, and sensorimotor gating deficits and mitigated the loss of dopamine neurons in the substantia nigra, in males, but not in females.
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| [IC 50]
ERβ: 6 nM (EC50); ERα: 5000 nM (EC50) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
|