| Identification | Back Directory | [Name]
Bromoacetamido-PEG3 -Boc-amine | [CAS]
1421933-39-2 | [Synonyms]
Bromoacetamido-PEG3-NH-Boc
Bromoacetamido-PEG3 -Boc-amine
Bromoacetamido-PEG4-t-Boc-N-Amide
tert-Butyl (1-bromo-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamate
5,8,11-Trioxa-2,14-diazahexadecanoic acid, 16-bromo-15-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H29BrN2O6 | [MDL Number]
MFCD23378554 | [MOL File]
1421933-39-2.mol | [Molecular Weight]
413.3 |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG3-Boc-amine is a PEG linker containing a Boc protected amine and a bromide group. The protected amine can be deprotected under mild acidic conditions. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|