| Chemical Properties | Back Directory | [Boiling point ]
976.6±65.0 °C(Predicted) | [density ]
1.314±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
1.83±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG3-DOTA is a PEG linker containing a bromine moiety and a t-butyl protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The DOTA group can be ionized and is susceptible for chelating di- and trivalent cations. | [Uses]
Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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