| Identification | Back Directory | [Name]
ML 18 | [CAS]
1422269-30-4 | [Synonyms]
ML 18
ML18, >98%
BRS-3 antagonist
ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4
(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE | [Molecular Formula]
C32H35N5O5 | [MOL File]
1422269-30-4.mol | [Molecular Weight]
569.65 |
| Chemical Properties | Back Directory | [Boiling point ]
821.8±65.0 °C(Predicted) | [density ]
1.291±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
11.99±0.46(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM). It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells. | [Uses]
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist. It also inhibits lung cancer growth. | [storage]
Store at -20°C | [References]
[1] TERRY W. MOODY . ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth[J]. Peptides, 2015, 64: Pages 55-61. DOI: 10.1016/j.peptides.2014.12.005 |
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