| Identification | Back Directory | [Name]
ML418 | [CAS]
1928763-08-9 | [Synonyms]
ML418
Carbamic acid, N-[1-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-4-piperidinyl]-, 1-methylethyl ester | [Molecular Formula]
C19H24ClN3O3 | [MDL Number]
MFCD32201056 | [MOL File]
1928763-08-9.mol | [Molecular Weight]
377.87 |
| Chemical Properties | Back Directory | [Boiling point ]
545.5±50.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
12.43±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders. | [in vivo]
ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution[1]. | Animal Model: | Rats and Mice[1] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal | | Result: | Showed a suitable PK profile (Cmax = 0.20 μM and Tmax = 3 h), excellent CNS penetration with a mouse brain: Kp of 10.9, brain (323.9 ng/g): plasma (29.5 ng/mL). |
| [storage]
Store at -20°C | [References]
[1] ML418, et al. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. DOI:10.1021/acschemneuro.6b00111 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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