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1422389-91-0

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1422389-91-0 Structure

1422389-91-0 Structure
IdentificationBack Directory
[Name]

Benzamide, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methyl-1-piperazinyl)-5-nitrophenyl]-
[CAS]

1422389-91-0
[Synonyms]

WDR5-47
2-Chloro-4-fluoro-3-methyl-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
Benzamide, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methyl-1-piperazinyl)-5-nitrophenyl]-
[Molecular Formula]

C19H20ClFN4O3
[MOL File]

1422389-91-0.mol
[Molecular Weight]

406.84
Chemical PropertiesBack Directory
[Boiling point ]

500.9±50.0 °C(Predicted)
[density ]

1.374±0.06 g/cm3(Predicted)
[pka]

10.86±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

WDR5-MLL1 antagonist 1 (compound 47) is a compound optimized through protein crystal structure guidance. It has stronger antagonistic activity against WDR5-MLL interaction with a dissociation constant (Kd) of 0.3μM.
[References]

[1] Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction
Spectrum DetailBack Directory
[Spectrum Detail]

Benzamide, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methyl-1-piperazinyl)-5-nitrophenyl]-(1422389-91-0)1HNMR
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