| Identification | Back Directory | [Name]
ML298 | [CAS]
1426916-02-0 | [Synonyms]
ML298
ML298 >=98% (HPLC)
Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]- | [Molecular Formula]
C22H23F3N4O2 | [MOL File]
1426916-02-0.mol | [Molecular Weight]
432.44 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml | [form ]
powder | [color ]
white to beige | [InChI]
1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31) | [InChIKey]
XAPVAKKLQGLNOY-UHFFFAOYSA-N | [SMILES]
Fc1c(ccc(c1)C(=O)NCCN2CCC3(N(CNC3=O)c4cc(ccc4)F)CC2)F |
| Hazard Information | Back Directory | [Description]
ML-298 is an inhibitor of phospholipase D2 (PLD2; IC50 = 355 nM). It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 μM without inducing cytotoxicity. | [Uses]
ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2). | [Biochem/physiol Actions]
ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2; IC50 = 355 nM). ML298 does not affect PLD1 activity at concentrations up to 20 μM. | [storage]
Store at -20°C | [References]
[1] MATTHEW C. O’REILLY. Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells[J]. Journal of Medicinal Chemistry, 2013, 56 6: 2695-2699. DOI: 10.1021/jm301782e |
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