| Identification | Back Directory | [Name]
DBCO-PEG4-SE | [CAS]
1427004-19-0 | [Synonyms]
DBCO-PEG4-SE
DBCO-PEG4-SPA
DBCO-PEG4-NHS ester
DBCO-CONH-PEG4-NHS ester
DBCO-PEG4-succinimidyl ester
Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
2,5-Dioxo-1-pyrrolidinyl 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-4,7,10,13-tetraoxa-16-azaeicosanoate
4,7,10,13-Tetraoxa-16-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C34H39N3O10 | [MDL Number]
MFCD26793797 | [MOL File]
1427004-19-0.mol | [Molecular Weight]
649.69 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
gel or oil | [pka]
15.14±0.46(Predicted) | [color ]
Colourless to yellow | [InChIKey]
RRCXYKNJTKJNTD-UHFFFAOYSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O |
| Hazard Information | Back Directory | [Description]
DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. | [Uses]
Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Applications Include:
- Protein-peptide conjugates
- Antibody-enzyme or antibody-drug conjugates
- Protein or peptide-oligonucleotide conjugates
- Surface modification
| [reaction suitability]
reaction type: click chemistry
reagent type: linker | [IC 50]
PEGs |
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