| Identification | Back Directory | [Name]
Mutant IDH1-IN-2 | [CAS]
1429176-69-1 | [Synonyms]
Mutant IDH1-IN-2
AG-881,Mutant IDH1-IN-2
Mutant IDH1 inhibitor 2
2-Oxazolidinone, 3-[2-[[(1S)-1-[4-[(4,4-difluoro-1-piperidinyl)methyl]phenyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-, (4S)- | [Molecular Formula]
C24H31F2N5O2 | [MDL Number]
MFCD29472262 | [MOL File]
1429176-69-1.mol | [Molecular Weight]
459.53 |
| Chemical Properties | Back Directory | [Boiling point ]
578.1±60.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (108.81 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
5.07±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.
Target: Mutant IDH1
Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224). | [IC 50]
IDH1 | [storage]
Store at -20°C | [References]
[1] Huangshu, et al. 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation |
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