| Identification | Back Directory | [Name]
ZTMSSDQFJNEUNG-WMMXXEOUSA-N | [CAS]
1429386-01-5 | [Synonyms]
ZTMSSDQFJNEUNG-WMMXXEOUSA-N
2-Morpholineacetic acid, 6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1S)-1-cyclopropyl-2-[(1,1-dimethylethyl)sulfonyl]ethyl]-3-oxo-, (2R,5R,6R)- | [Molecular Formula]
C27H31Cl2NO6S | [MDL Number]
MFCD28963896 | [MOL File]
1429386-01-5.mol | [Molecular Weight]
568.51 |
| Hazard Information | Back Directory | [Description]
AM-8735 is a selective and potent inhibitor of the MDM2-p53 protein-protein interaction. | [Uses]
AM-8735 is a potent and selective MDM2 inhibitor with an IC50 of 25 nM. | [in vivo]
AM-8735 also demonstrates significant time and concentration dependent p21 mRNA induction in vivo in a pharmacodynamic assay in SJSA-1 osteosarcoma tumors. AM-8735 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with an ED50 of 41 mg/kg[1]. | [storage]
Store at -20°C | [References]
[1] Gonzalez AZ, et al. Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem. 2014 Mar 27;57(6):2472-88. DOI:10.1021/jm401767k |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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