| Identification | Back Directory | [Name]
WAY-267464 dihydrochloride | [CAS]
1432043-31-6 | [Synonyms]
WAY267464 HCl
WAY-267464 dihydrochloride >=98% (HPLC) | [Molecular Formula]
C32H36ClN7O4 | [MOL File]
1432043-31-6.mol | [Molecular Weight]
618.14 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble to 80 mM in DMSO and to 5 mM in water | [form ]
Powder | [color ]
white to beige | [Water Solubility ]
H2O: 2mg/mL, clear | [InChIKey]
OTFWXMFLPMUDFP-UHFFFAOYSA-N | [SMILES]
O=C(NCC1=CC=C(C=C1C)C(N2CC3=C(NC4=CC=CC=C24)N(N=C3)C)=O)N5CCN(CC5)CC6=CC(O)=CC(O)=C6 |
| Hazard Information | Back Directory | [Uses]
WAY 267464 Dihydrochloride is an oxytocin receptor agonist. | [Biological Activity]
WAY-267464 is a non-peptide drug with a novel mechanism of action (MOA) to tre at psychosis and schizophrenia.''WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist (EC50 = 61-881 nM; Ki = 58-978 nM) thatunlike oxytocin (OT)displays antagonist instead of agonist activity toward vasopressin V1a receptor/V1aR (IC50 = 613 nM; Ki = 27-113 nM). WAY-267464 exhibits OT-like anxiolytic effects in assays measuring both behavioral (33% increase in punished crossing by 10 mg/mL ip or 10 μg/mouse icv in four-plate tests; 75% increased open quadrants stay by 3 μg/mouse icv in elevated zero maze) and autonomic (47% higher stress-induced hyperthermia by 10 μg/mouse icv) parameters of the anxiety response. Similar to the antipsychotic-like effects reported for OTWAY-267464 also reverses disruption in prepulse inhibition of the acoustic startle reflex induced by either MK-801 or amphetamine. Unlike OTWAY-267464 does not affect immob | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|